Ethical dilemmas in medicine arise when the clinician’s duty to act according to the principles of beneficence, autonomy, nonmaleficence, and justice conflict with the preferences of the patient, family, or other clinicians providing care. Navigating Clinical Ethics When Autonomy and Beneficence Collide provides effective strategies to help clinicians: (1) counsel patients about medical misinformation, (2) respond when patients or families refuse to follow evidence-based care recommendations, and (3) resolve disagreements about the benefit of care interventions for seriously ill patients.