FIGURE 1. Normal Interactions Between LDL and LDL-R

ACAT = Acyl CoA, or cholesterol acyl transferase; CoA = coenzyme A; HMG CoA = 3-hydroxy-3-methyl-glutaryl-CoA; LDL = low-density lipoprotein.
Reprinted with permission from Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009;29(4):431-438.