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TABLE 1. Overview of PrEP, PEP, and TasP
Use Advantages Disadvantages
Pre-exposure prophylaxis
(PrEP)
Before HIV exposure Highly effective at preventing HIV infection when drug is taken as prescribed
  • Potentially high cost, depending on insurance coverage
  • Does not protect from other STIs (eg, chlamydia, gonorrhea, syphilis)
  • Only 1 medication is currently available
Post-exposure prophylaxis (PEP) Within 72 hours of a potential HIV exposure Reduces the likelihood that HIV will spread throughout the body
  • Potentially high cost, depending on insurance coverage
  • Multiple medications required
  • Must start within 72 hours of exposure
  • Must take daily for 28 days
Treatment as prevention (TasP) After HIV diagnosis Highly effective at controlling an individual’s viral load and preventing HIV transmission to others
  • Potentially high cost, depending on insurance coverage
  • Multiple medications required
  • Lifetime use