| ALL |
| Takeuchi 20026 |
100 mg/m2 bolus, then 500 mg/m2 as a 4-hour infusion |
4 hours |
15 mg every 6 hours for 8 doses |
28 hours |
| Linker 20027 |
220 mg/m2 bolus, then 60 mg/m2 per hr x 36 hours |
36 hours |
50 mg/m2 IV every 6 hours for 3 doses, then orally until serum MTX < 0.05 μM |
36 hours |
| Han 20018; Hill 20049 |
8 g/m2 (age ≤ 4)
6 g/m2 (age > 4) |
10% bolus, remainder over 23 hours |
15 mg/m2 every 3 hours, then every 6 hours when serum MTX
< 2 x 106 μM |
36 hours |
| Pui 200410 |
2 g/m2 |
2 hours |
10 mg/m2 every 6 hours |
44 hours |
| Asselin 20113 |
5 g/m2 (0.5 g/m2 bolus over 30 minutes, then 4.5 g/m2 over 23.5 hours) |
24 hours |
75 mg/m2 then 15 mg/m2 every 6 hours until serum MTX ≤ 0.1 μM |
36 hours |
| CNS Lymphoma |
| Ferreri 20094; Joerger 201011 |
3.5 g/m2 (0.5 g/m2 in 15 minutes, then 3 g/m2 as a 3- hour infusion) |
3 hours, 15 minutes |
15 mg/m2 every 6 hours for 12 cycles or until serum MTX levels are undetectable |
24 hours |
| Osteosarcoma |
| Souhami 199712 |
8 g/m2 (≥ 12 years old)
12 g/m2 (< 12 years old)
|
Not specified |
12 mg/m2 IV or 15 mg/m2 orally every 6 hours for 10 doses |
24 hours |
| Fuchs 199813 |
12 g/m2 (maximum 20 g) |
Not specified |
15 mg/m2 every 6 hours for 12 doses |
Not specified |
| Bacci 200114 |
12 g/m2 (escalate to 14 g/m2 if 6-hr serum MTX < 1 μM) |
6 hours |
15 mg every 6 hours for 11 doses |
24 hours |
| Goorin 200315 |
12 g/m2 |
4 hours |
15 mg every 6 hours for 10 doses |
24 hours |
| Ferrari 200516 |
12 g/m2 |
4 hours |
8 mg/m2 every 6 hours for 11 doses |
24 hours |
| Holmboe 201217 |
Mean dose, 12 g/m2
(range, 8-16 g/m2) |
4 hours |
Standard dosing until serum MTX ≤ 0.2 μM |
24 hours |
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