Emergency Medicine Differentials: Accounting for the Rare provides case scenarios that highlight the importance of remaining objective in the assessment of back pain, including generating a broad differential, for patients who visit EDs often and who are thought to be seeking drugs, describing the rationale for expanding upon previous providers’ differential diagnoses when a patient’s skin condition is not improving as expected, and repeating a workup and testing to avoid missing symptoms of stroke when a patient continues to have troublesome neurologic symptoms.