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Long-Term Risks and Benefits of Costimulation Blocker Therapy After Kidney Transplantation
Med-IQ Express Med-IQ Express

Long-Term Risks and Benefits of Costimulation Blocker Therapy After Kidney Transplantation


This activity was developed by Med-IQ in collaboration with Duke University Health System Department of Clinical Education and Professional Development.

Med-IQ      Duke Medicine
 

Released:
12/22/17
Expires:
12/21/18

Maximum Credits:

0.25
By clicking "Continue," you are confirming that you have reviewed the CME information and read, understood, and unconditionally agreed to the Privacy Notice and Terms of Use.

Med-IQ Express Med-IQ Express
By clicking "Continue," you are confirming that you have reviewed the CME information and read, understood, and unconditionally agreed to the Privacy Notice and Terms of Use.
Released:
12/22/17

Expires:
12/21/18

Maximum Credits:
0.25
Med-IQ Express Med-IQ Express
By clicking "Continue," you are confirming that you have reviewed the CME information and read, understood, and unconditionally agreed to the Privacy Notice and Terms of Use.

Released:
12/22/17
Expires:
12/21/18


Maximum Credits:
0.25


Overview: This 15-minute activity features a brief video introduction by faculty expert Matthew Ellis, MD, who discusses the rationale for using costimulation blocker therapy in patients following kidney transplantation. The activity then continues with a text-based review of the risks and benefits of using costimulation blockade for immunosuppression after kidney transplantation, including mechanism of action, efficacy, and safety.

CME Information:

Faculty
Matthew J. Ellis, MD
Medical Director of Kidney & Pancreas Transplantation
Associate Professor of Medicine, Nephrology 
Assistant Professor of Surgery, Abdominal Transplant
Duke University Medical Center
Durham, NC
 
Activity Planners
Iwona Misiuta, PhD, MHA
Clinical Content Manager
Med-IQ
Baltimore, MD
 
Laura Rafferty, ELS
Managing Editor
Med-IQ
Baltimore, MD
 
Samantha Gordon
CME Specialist
Med-IQ
Baltimore, MD
 
Kathryn Schaefer, MSN, RN
Manager
Lead Nurse Planner
Med-IQ
East Lansing, MI
 
Writer
Katherine Kahn                                            
Holyoke, MA
 
Learning Objectives
Upon completion, participants should be able to:

  • Evaluate the risks and benefits of costimulation blockade as immunosuppression after kidney transplantation

Target Audience
This activity is intended for nephrologists.
 
Series Overview/Statement of Need
Over the last two decades, long-term kidney graft survival and patient outcomes after kidney transplantation have not dramatically improved. Since the 1980s, the mainstay of immunosuppressive maintenance therapy in kidney transplantation has been calcineurin inhibitors (CNIs). Despite their effectiveness as immunosuppressive agents, CNIs are associated with chronic nephrotoxicity, interstitial fibrosis, tubular atrophy, and deteriorating graft function, all of which can ultimately lead to graft failure. In 2011, the United States Food and Drug Administration approved the first-in-class, selective costimulation blocker, belatacept, for immunosuppression in kidney transplantation. To achieve optimal patient outcomes, nephrologists must be familiar with the mechanism of action, efficacy, and safety of belatacept.
 
Collaborator Statement
This activity was developed by Med-IQ in collaboration with Duke University Health System Department of Clinical Education and Professional Development.

Accreditation/Designation Statements
Med-IQ is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
 
Med-IQ designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
 
Nurse practitioners, physician assistants, and other healthcare professionals who successfully complete the activity will receive a Statement of Participation indicating the maximum credits available.
 
Medium/Method of Participation
This CME activity consists of a 0.25-credit online publication. To receive credit, read the introductory CME material, read the publication, and complete the evaluation, attestation, and post-test, answering at least 70% of the post-test questions correctly.
 
Initial Release Date: December 22, 2017
Expiration Date: December 21, 2018
Estimated Time to Complete This Activity: 15 minutes
 
Disclosure Policy
Med-IQ requires any person in a position to control the content of an educational activity to disclose all relevant financial relationships with any commercial interest. The ACCME defines “relevant financial relationships” as those in any amount occurring within the past 12 months, including those of a spouse/life partner, that could create a conflict of interest (COI). Individuals who refuse to disclose will not be permitted to contribute to this CME activity in any way. Med-IQ has policies in place that will identify and resolve COIs prior to this educational activity. Med-IQ also requires faculty to disclose discussions of investigational products or unlabeled/unapproved uses of drugs or devices regulated by the US Food and Drug Administration.
 
Disclosure Statement
The content of this activity has been peer reviewed and has been approved for compliance. The faculty and contributors have indicated the following financial relationships, which have been resolved through an established COI resolution process, and have stated that these reported relationships will not have any impact on their ability to give an unbiased presentation. 
 
Matthew J. Ellis, MD
Consulting fees/advisory boards: Bristol-Myers Squibb
Fees received for promotional/non-CME activities: Bristol-Myers Squibb
 
The writer, peer reviewers, and activity planners have no financial relationships to disclose.

Statement of Evidence-Based Content
Educational activities that assist physicians in carrying out their professional responsibilities more effectively and efficiently are consistent with the ACCME definition of continuing medical education (CME). As an ACCME-accredited provider of CME, it is the policy of Med-IQ to review and ensure that all the content and any recommendations, treatments, and manners of practicing medicine in CME activities are scientifically based, valid, and relevant to the practice of medicine. Med-IQ is responsible for validating the content of the CME activities it provides. Specifically, (1) all recommendations addressing the medical care of patients must be based on evidence that is scientifically sound and recognized as such within the profession; (2) all scientific research referred to, reported, or used in CME in support or justification of a patient care recommendation must conform to generally accepted standards of experimental design, data collection, and analysis.
 
Med-IQ is not liable for any decision made or action taken in reliance upon the information provided through this activity.
 
Contact Information       
For questions or comments about this activity, please contact Med-IQ.
Call (toll-free) 866 858 7434 or email info@med-iq.com.
 
Hardware/Software Requirements
Operating System
Microsoft Windows® 8, Windows 7
Mac OS 10.7 (Lion) or newer

Browser
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PDF Viewer
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Adobe Flash Player
Adobe Flash Player 9 or later
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ADA Statement
Med-IQ fully complies with the legal requirements of the ADA and the rules and regulations thereof. If any participant in this educational activity is in need of accommodations, please contact Med-IQ at 443 543 5200.
 
Disclaimer
The information provided through this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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Copyright
© 2017 Med-IQ, LLC and Duke University Health System

 

 

Unless otherwise indicated, photographed subjects who appear within the content of this activity or on artwork associated with this activity are models; they are not actual patients or doctors.

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